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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12347 | p38-α MAPK-IN-1 | p38 MAPK , Autophagy | |
p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor(IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay). | |||
T16424 | p38 MAPK-IN-1 | p38 MAPK | |
p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM). | |||
T9697 | ASK1-IN-1 | ASK | |
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays. | |||
T63119 | NF-κB/MAPK-IN-1 | NF-κB , MAPK | |
NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition of LPS-induced activation of iNOS, COX-2, ERΚ and P38. NF-κ... | |||
T6934 | Pexmetinib | ARRY-614 | Tie-2 , p38 MAPK , Autophagy |
Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1. | |||
T5S2283 | Sesamolin | p38 MAPK , Caspase , JNK | |
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can s... | |||
T5S1058 | Triptonide | PG 492,NSC 165677 | Apoptosis , Wnt/beta-catenin , Autophagy |
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an... | |||
T2367 | SKF-86002 | SKF86002 | p38 MAPK , TNF |
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM). | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T3763 | Fumaric acid | Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,Donitic acid,Allomaleic acid | Endogenous Metabolite |
Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or a... | |||
T2768 | Saikosaponin A | NF-κB , Antibacterial , Liver X Receptor | |
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath... | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
T6429 | Caffeic Acid Phenethyl Ester | Phenylethyl Caffeate,CAPE | Apoptosis , NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective... | |||
T3S0737 | Flavokawain A | Flavokavain A | Apoptosis , p38 MAPK |
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant... | |||
T6S1572 | Sauchinone | ERK , p38 MAPK , NF-κB | |
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative... | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
T4S2326 | Cornuside | 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside | ERK , p38 MAPK , NF-κB , JNK |
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi... | |||
T26280 | TL4-12 | TL4 12 | |
TL4-12 is a MAP4K2 (GCK) inhibitor that inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. | |||
T61803 | p38 MAPK-IN-3 | ||
p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, displaying antitumor properties by promoting apoptosis and increasing reactive oxygen species (ROS) production [1]. | |||
T61091 | p38-α MAPK-IN-4 | ||
p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM. It effectively and swiftly mitigates the onset of mechanical allodynia (MA) in vivo [1]. |